Dr Anna Walduck

Senior Lecturer in Applied Microbiology, Laboratory Head
Biosciences
RMIT University

399257145
anna.walduck@rmit.edu.au

Research Activities

We are interested in the interactions between host and pathogen in acute and chronic infections.
Including: 
Severe sepsis- Sepsis has a high mortality rate, there is an urgent need for adjunct therapies to improve patient outcomes. We are investigating immunological responses in patients with sepsis and looking at the potentially positive effects of low dose aspirin. This study is supported by experiments in animal and in vitro models of sepsis and biofilm related infections.  

Understanding inflammation in the stomach to guide development of new vaccines against Helicobacter pylori. This bacterium infects up to half of the world population and causes chronic, potentially fatal disease. We are investigating the complex regulation of inflammation in the stomach to understand how to better design vaccines.  

Novel Wound dressings using silver nano-structured fabrics.
In collaboration with Prof. Vipul Bansal's group ( RMIT) we are developing wound infection models to test novel wound dressings based on TCNQ. These fabrics have strong anti-microbial properties and are predicted to also enhance wound healing. See: https://www.rmit.edu.au/news/all-news/2016/april/nano-enhanced-textiles-clean-themselves-with-light/

2017:
Two new projects on novel vaccination strategies in poultry:
1)    Development of methods for the selection and delivery of vaccine antigens and other biologically active proteins using live microbial vectors. This project will design and test antigen expression constructs that will investigate different approaches to deliver multiple antigens in the most effective way, using live microbes as delivery vehicles.  
2)    Development of methods to enhance specific immune responses to vaccine antigens. There are opportunities to improve the effectiveness of vaccines by enhancing the quality, magnitude, and specificity of appropriate immune responses. The project will investigate the use of immune-enhancement sequences and co-delivered cytokines.  

  Both projects will be co-supervised by Professor Robert Moore and Dr Anna Walduck.

Techniques/Expertise

Mouse models of infection
vaccination
 flow cytometry
 immunohistochemistry

Collaborations

Dr Odilia Wijburg
Assoc. Prof Damon Eisen (Victorian Infectious Disease Service), Dr Sukanya Raghavan (University of Gothenburg)
Prof Vipul Bansal & Dr Rajesh Ramanathan ( RMIT NanoBiotechnology Research Lab, Ian Potter NanoBioSensing Facility)

Disease Models

H. pylori mouse model, vaccination
vaccination models in mice using attenuated Salmonella
S. aureus sepsis
Infection models in Leptin deficient mice ( ob/bo & db/db)
 Immune responses to vaccination in poultry

Other Lab Members

Jacinta Ortega ( PhD candidate)
Dipesh Kumar ( Masters by Research)

Research Images

Other members with similar research interests

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Prof Hans Netter

Victorian Infectious Diseases Reference Laboratory Melbourne Health SEE FULL PROFILE >

Dr Ben Croker

Hematology/Oncology Boston Children's Hospital SEE FULL PROFILE >

Dr Louis Schofield

Infection and Immunity Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Upcoming Events

  • Nov 27

    Australasian Society for Immunology 2017 Annual Scientific Meeting

    Brisbane Convention and Exhibition Centre REGISTER | MORE INFO
  • Nov 29

    Microbiome in Sexual, Maternal and Child Health Symposium

    AMREP Lecture Theatre REGISTER | MORE INFO
  • Dec 3

    MICROMON Molecular Biology Techniques 2017: An introductory course in recombinant DNA technology

    Monash University REGISTER | MORE INFO