Dr Michael Gantier

ARC Future Fellow
Centre for Cancer Research
Hudson Institute of Medical Research

+61 3 8572 2709
michael.gantier@monash.edu

Latest News

Australian students looking for a PhD are welcome to contact us!

Research Activities

Our laboratory is interested in defining how nucleic acids control the interface between host and pathogens, and how this can lead to inflammatory diseases (as seen in Systemic Lupus Erythematosus).
With several new nucleic acids-based therapies now approved for use in humans (to treat diseases such as spinal muscular atrophy), understanding how synthetic nucleic acids can influence normal immune responses is important. In addition, synthetic nucleic acids can be devised to curb pathogens infections, presenting high potential against emerging global threats. Finally many chemotherapies directly interact with nucleic acids, indirectly engaging our immune system.  
Our group has made significant findings relevant to these themes – for instance recently describing how acriflavine, a century old antiseptic which binds DNA, can also induce immune responses protective against viruses.

Techniques/Expertise

Sensing of endogenous DNA products by the cGAS-STING pathway
miRNA research - dynamic modulation of innate immune responses
TLR7/8 biology - RNA sensing including sensing of viruses and intracellular bacteria

Collaborations

Prof Bryan Williams
Dr Cameron Stewart
Prof Eicke Latz
Dr Mark Behlke
Prof Wei Duan
Dr Claire McCoy
Dr Di Wu
Dr Michelle Tate
Dr Maria Liaskos
A/Prof Richard Ferrero
Prof Veit Hornung
A/Prof Marcel Nold
Prof Paul Hertzog

Disease Models

Viral infections (IAV, rhinovirus, SFV), SLE, Salmonella and H pylori infections. 

Other Lab Members

Dr Jonathan Ferrand
Dr Genevieve Pepin
Ms Charlotte Nejad

Other members with similar research interests

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Dr Le Son Tran

Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research SEE FULL PROFILE >

Dr Michelle Tate

Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research SEE FULL PROFILE >

Dr Sammy Bedoui

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Upcoming Events

  • Nov 27

    Australasian Society for Immunology 2017 Annual Scientific Meeting

    Brisbane Convention and Exhibition Centre REGISTER | MORE INFO
  • Nov 29

    Microbiome in Sexual, Maternal and Child Health Symposium

    AMREP Lecture Theatre REGISTER | MORE INFO
  • Dec 3

    MICROMON Molecular Biology Techniques 2017: An introductory course in recombinant DNA technology

    Monash University REGISTER | MORE INFO