A/Prof Neil O'Brien-Simpson

Program Leader
Melbourne Dental School
University of Melbourne

+61 3 9341 1550
neil.obs@unimelb.edu.au

Research Activities

  1. Host repsonse to bacterial outer membrane vesicles (OMVs)
  2. Vaccine design and development - synthetic peptides and recombinant proteins
  3. Evaluation of the host response to bacterial oral infection
  4. Role of γδT cells, NKT cells and innate immune cells in bacterial oral infection
  5. Antimicrobial peptide development

Techniques/Expertise

  1. Peptide synthesis and modification, HPLC etc.
  2. Flow cytometry, Bioplex, MACS and FACS sorting, T cell proliferation, cytokine assays (ELISPOT, Bioplex), cell culture (T cells and subsets, B cells, macrophages, epithelial, endothelial etc)

Collaborations

2. Prof Dale Godfrey (Dept Immunology and Microbiology, University of Melbourne).
3. Prof Malcolm McConville (Dept Biochemistry, University of Melbourne)1
Prof John Wade (Howard Florey Institute)
Prof Greg Qiao (Dept Engineering, University of Melbourne)
Dr Maria Liaskos

Disease Models

Bacterial induced bone loss
bacterial induced periotonitis

Genetically Modified Organisms

αβ-TCR-/-, γδTCR-/-, IL-4-/-, IL-13-/-

Other Lab Members

Ms Yan Tan (Research assistant)
Ms Gail Brammar (Research assistant), two PhD students
Dr Jason Lenzo
Dr James Holden

Other members with similar research interests

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Prof Robert Pike

La Trobe Institute for Molecular Science La Trobe University SEE FULL PROFILE >

Dr Maria Liaskos (Kaparakis-Liaskos)

Department of Physiology, Anatomy and Microbiology La Trobe University SEE FULL PROFILE >

Dr Mohammad Azad

Monash Institute of Pharmaceutical Sciences Monash University SEE FULL PROFILE >

Upcoming Events

  • Feb 14

    Lorne Infection and Immunity Conference 2018

    Cumberland Lorne Resort REGISTER | MORE INFO
  • Mar 1

    18th International Congress on Infectious Diseases

    Sheraton Buenos Aires MORE INFO
  • Mar 15

    Eradicate Cancer 2018

    Melbourne Convention and Exhibition Centre MORE INFO