Prof Sharon Lewin

Director
Peter Doherty Institute
University of Melbourne

+61 3 8344 3159
sharon.lewin@unimelb.edu.au

Contract research opportunities

  • HIV viral isolation and culture for clinical and basic research
  • Quantification of HIV viral RNA and DNA in patient samples
  • Establishing and maintaining prospective clinical cohorts
  • PBMC isolation and storage
  • Specialised flow cytometry
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Latest News

  • In November 2015, Professor Lewin was the recipient of Research Australia’s prestigious Peter Wills Medal in recognition of her extraordinary contribution to research into HIV, the international recognition she has received for her work, her contribution to the community, and the leadership she has shown for women in science. Sharon has been working in the field of HIV for over 20 years and is internationally renowned for her HIV cure research. She has published over 200 publications and has been continually funded by the National Health and Medical Research Council (NHMRC) since 1993. She leads a large, multi-disciplinary research team

Research Activities

Professor Sharon Lewin is the inaugural Director of the Doherty Institute for Infection and Immunity, a joint venture between the University of Melbourne and Melbourne Health (Royal Melbourne Hospital). Professor Lewin is an Infectious Diseases Physician and basic scientist, she is also an Adjunct Professor with the Department of Infectious Diseases, Monash University and Alfred Hospital, and with the Department of Microbiology and Immunology, University of Melbourne.

Professor Lewin's laboratory focuses on both clinical trials and laboratory based pathogenesis studies. Her laboratory investigates the mechanisms of CD4+ T-cell reconstitution, the role of dendritic cells and CD4+ T-cells in long term HIV persistence and latency and strategies to reverse HIV latency using novel therapies.

Her laboratory has also had a long standing interest in hepatitis B virus and HIV-HBV co-infection, understanding accelerated liver disease in HIV-HBV co-infection and understanding the immune response to HBV.

Techniques/Expertise

  • Clinical trials 
  • HIV viral culture, quantification, infection 
  • In vitro models of HIV latency 
  • Multiparameter flow cytometry including high speed cell sorting 
  • Real-time PCR 
  • Expansion of intra-hepatic T-cells 
  • Establishing and maintaining prospective clinical cohorts

Collaborations

HIV (National):
A/Prof Melissa Churchill (Burnet Inst, Melbourne)
Dr Lachlan Gray
Professor Suzanne Crowe AM
A/Prof Anthony Jaworowski
Prof Stephen Kent
Prof Damian Purcell (Doherty Inst, University of Melbourne)
A/Prof Edwina Wright (Monash Uni, Alfred Health, Melbourne)
Dr Julian Elliott (Monash Uni, Alfred Health, Melbourne)
Prof Jennifer Hoy (Monash Uni, Alfred Health, Melbourne)
Prof Paul Gorry (RMIT, Melbourne)
Prof Johnson Mak (Deakin CSIRO, Geelong)
A/Prof Sarah Palmer (Westmead Millenium Inst, Sydney)
Prof Tony Cunningham (Westmead Millenium Inst, Sydney)
Prof Graeme Stewart (Westmead Millenium Inst, Sydney)
A/Prof David Booth (Westmead Millenium Inst, Sydney)
Prof Miles Davenport (University of NSW, Sydney)
Prof Martyn French (University of Western Australia, Perth)
Professor Simon Mallal (Murdoch University, Perth)
A/Prof Di Yu (Monash University)
HIV (International):
Prof Steve Deeks (UCSF, San Fransisco, USA)
Prof Mike McCune (UCSF, San Francisco, USA)
Dr Afam Okoye (Oregon Health Sciences Univ, Portland, USA)
Dr Jake Estes (National Cancer Inst, Frederick, USA)
Dr Jeff Lifson (National Cancer Inst, Frederick, USA)
Dr Richard Barnard (Merck, West Point, USA)
Prof David Margolis (University of North Carolina, Durham, US)
Dr Nicolas Chomont (U. Montreal, Montreal, Canada)
Dr Remi Fromentin (U. Montreal, Montreal, Canada)
Dr Thomas Rasmussen (Aarhus Uni, Aarhus, Denmark)
A/Prof Martin Tolstrup (Aarhus Uni, Aarhus, Denmark)
Prof Lars Ostergaard (Aarhus Uni, Aarhus, Denmark)
Dr Timothy Henrich (Brigham and Women's Hospital, Cambridge, UK)
Prof Philip Goulder (U. Oxford, London, UK)
Prof Thumbi Ndungu (U. of KwaZulu-Natal, Durban, South Africa)
Dr Reena Rajasuriar (U. Malaya, Kuala Lumpur, Malaysia)
Adeeba Kamarulzaman (U. Malaya, Kuala Lumpur, Malaysia)
Dr Jintanat Ananworanich (US Military HIV Research Program, Bethesda, USA)
Dr Leslie Cockerham (Medical College of Wisconsin, USA)
Dr Mike Busch (San Francisco Blood Bank, UCSF, San Franscisco)
Dr Sheila Keating (San Francisco Blood Bank, UCSF, San Francisco)
HBV (National):
Prof Stephen Locarnini (VIDRL, Royal Melbourne Hospital at the Doherty Institute, Melbourne)
Dr Scott Bowden (VIDRL, Royal Melbourne Hospital at the Doherty Institute, Melbourne)
Dr Joe Sasadeusz (VIDS, Royal Melbourne Hospital at the Doherty Institute, Melbourne)
A/Prof Gail Matthews (Kirby Inst, Sydney)
Dr Lloyd Einsendel (Flinders Uni, Adelaide)
HBV (International):
Dr Anchalee Avahingsanon (HIV Netherlands Australia Thailand Collaboration, Thai Red Cross, Bangkok, Thailand)
A/Prof Kiat Ruxrungtham (HIV Netherlands Australia Thailand Collaboration, Thai Red Cross, Bangkok, Thailand)
Dr Chloe Thio (Johns Hopkins, Baltimore, USA)
Dr Angela Kashuba (University of North Carolina, Durham, NC)
Dr Jake Estes (National Cancer Institute, Frederick, MD)
Industry:
Richard Barnard and Daria Hazuda, Merck
David Favre, GSK
Glenn Begley, Tetralogic
Jeff Symons, Callimune
Fraser Drummond, Viiv Healthcare

Disease Models

HIV Latency
HIV-HBV co-infection
DC-T-cell models

Other Lab Members

Lab Heads:
Prof Sharon Lewin
A/Prof Paul Cameron
Senior Scientists:
Dr Megan Crane (Post-doctoral Research Fellow)
Dr Jenny Anderson (Post-doctoral Research Fellow)
Dr Judy Chang (Head, Immunology core)
Post-doctoral Fellows:
Dr Hao Lu (Post-doctoral Research Fellow)
Dr Renee van der Sluis (Post-doctoral Research Fellow)
Dr Jennifer Audsley (Clinical Research Fellow)
Dr Michael Roche (NHMRC Early Career Fellow)
Dr Jori Symons (Post-doctoral Research Fellow)
Dr Vanessa Evans (Post-doctoral Research Fellow, maternity leave)
Research Assistants:
Ajantha Solomon (Laboratory Manager)
Surhekha Tanakoon (Research Assistant)
Ashanti Dantanarayana (Research Assistant)
Carolin Tumpach (Research Assistant)
Fiona Wightman (Research Assistant)
Students:
Talia Mota (PhD student)
Dr Kasha Singh (PhD Student)
Dr Michelle Yong (PhD Student)
Simin Rezaei (PhD Student)
Youry Lim (PhD Student)
Dr Matthew Pitman (PhD student, NHMRC Dora Lush Biomedical Research Postgraduate Scholar and RACP NHMRC CRB Blackburn Scholar)
Zuwena Richardson (PhD student)

Other members with similar research interests

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Dr Jacqueline Flynn

School Health and Biomedical Sciences RMIT University SEE FULL PROFILE >

Prof Stephen Locarnini

Research and Molecular Development Victorian Infectious Diseases Reference Laboratory SEE FULL PROFILE >

Prof Marc Pellegrini

Infection and Immunity Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Upcoming Events

  • Nov 27

    Australasian Society for Immunology 2017 Annual Scientific Meeting

    Brisbane Convention and Exhibition Centre REGISTER | MORE INFO
  • Nov 29

    Microbiome in Sexual, Maternal and Child Health Symposium

    AMREP Lecture Theatre REGISTER | MORE INFO
  • Dec 3

    MICROMON Molecular Biology Techniques 2017: An introductory course in recombinant DNA technology

    Monash University REGISTER | MORE INFO