Prof Brendan Jenkins

Laboratory Head
Centre for Innate Immunity and Infectious Diseases
Hudson Institute of Medical Research

brendan.jenkins@monash.edu

Research Activities

In vivo models assessing the mechanisms by which imbalanced STAT1 and STAT3 signalling from the IL-6 cytokine family common receptor gp130 contribute to inflammation, tumourigenesis, dysregulated lympho-hematopoiesis and bone metabolism

Techniques/Expertise

Gene targeting, mammalian cell culture techniques, immuno-detection techniques (eg immunohistochemistry, ELISA, Western blotting, flow cytometry), quantitative RT-PCR analyses

Collaborations

Simon Jones/Nicholas Topley (Cardiff, UK)
Andrew Robers (WEHI, Melbourne)
Matthias Ernst (Ludwig, Melbourne)
Robyn Starr (St Vincents Institute, Melbourne)
Matthew Gillespie and Jack Martin (St Vincents Institute, Melbourne)
Jane Armes (Mater Hospital, Brisbane)

Disease Models

Inflammation (peritonitis, endotoxic shock), gastric cancer, hematopoietic (spenomegaly, thrombocytosis) and lymphoid (lymphadenopathy) disorders , dysregulated bone metabolism.

Genetically Modified Organisms

gp130 knock-in mouse mutants crossed with STAT1/3, IL-6 and IL-11R KO mice

Other Lab Members

2 Research Assistants and 1 UROP student

Other members with similar research interests

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Prof Stephen Turner

Department of Microbiology Monash University SEE FULL PROFILE >

Dr Ashraful Haque

Department of Microbiology and Immunoloty University of Melbourne, Doherty Institute SEE FULL PROFILE >

Dr Latasha Abeynaike

Respiratory/Monash University Dept Immunology Alfred Hospital SEE FULL PROFILE >

Upcoming Events

  • Oct 21

    Infectious Diseases Week 2020

    Pennsylvania Convention Center MORE INFO
  • Nov 1

    Cytokines 2020

    MORE INFO
  • Nov 5

    The 18th Asia Pacific Congress of Clinical Microbiology and Infection

    MORE INFO