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Metabolomics,Pharmacology,Parasitology,Malaria,Trypanosomiasis
Metabolomics and systems biology analysis of microbial pathogens to discover new drug targets and elucidate the mechanisms of action and resistance for existing drugs and novel antimicrobial compounds.
Metabolomics
Proteomics
Plasmodium falciparum cell culture and drug assays
Trypanosoma brucei cell culture and drug assays
LC-MS
Systems pharmacology
Prof Jian Li,Prof Jonathan Baell,Prof Susan Charman,Prof Leann Tilley,Prof Malcolm McConville,Dr Stuart Ralph,Prof Mike Barrett,Prof Andy Waters,Prof Dominique Soldati-Favre,A/Prof Bayden Wood,A/Prof Sunil Parikh,Prof Karen Day,Prof Tania de Koning-Ward,Dr Michael Duffy
Malaria (in vitro)
Trypanosomiasis (in vitro)
Drug induced liver injury (in vitro)
orcid.org/0000-0001-7497-7082
Darren Creek
Dr Ghizal Siddiqui,Dr Anubhav Srivastava,Dr Dovile Anderson
Director of Metabolomics node of Monash Proteomics and Metabolomics Facility.
- Metabolic rewiring of bacterial subpopulations governs polymyxin responses in Acinetobacter baumannii.
- Uncovering an alternate pathway of antibiotic resistance in spore-forming bacteria.
- Real-Time Evaluation of Gastrointestinal pH and Transit Time in Patients With Essential Hypertension.
- Suppression of Post-Ischemic Cardiac Remodelling and Inflammatory Response by a Novel Sphingolipid Modifier, CIN038.
- Potent reaction hijacking inhibitors of Plasmodium falciparum asparagine tRNA synthetase.
- Correction to "Novel Scaffold Unlocks Potent Cross-Peptidase and Cross-Species Inhibitors as Promising Antimalarial Agents".
- Bioactive cationic lipidated oligomers (CLOs) as antimicrobial materials: metabolomic insights into MRSA membrane disruption.
- CD47 stabilizes ROBO2 to regulate glioblastoma progression by preventing ITCH-mediated ubiquitination.
- The Plasmodium falciparum PPCS is a unique heteromeric complex with prokaryote-like activity and is a target of pantothenate analogs.
- Novel Scaffold Unlocks Potent Cross-Peptidase and Cross-Species Inhibitors as Promising Antimalarial Agents.
- Deconvolution of the On-Target Activity of Plasmepsin V Peptidomimetics in Plasmodium falciparum Parasites.
- Preintervention Intake of Whole Grains Versus Refined Grains, and the Gut Microbiome, Discriminate the Antihypertensive Effect of Prebiotic Fiber.
- Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites.
- Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.
- SCFA biotherapy delays diabetes in humanized gnotobiotic mice by remodeling mucosal homeostasis and metabolome.
- Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.
- Maternal Diet and Gut Microbiota Influence Predisposition to Cardiovascular Disease in Offspring.
- Multiplexed Native Mass Spectrometry Determination of Ligand Selectivity for Fatty Acid-Binding Proteins.
- Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy.
- On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.
- Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy.
- Identifying and mathematically modeling the time-course of extracellular metabolic markers associated with resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa.
- Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites.
- Prebiotic intervention with HAMSAB in untreated essential hypertensive patients assessed in a phase II randomized trial.
- Use of Human Lung Tissue Models for Screening of Drugs against SARS-CoV-2 Infection.
- Systematic Down-Selection of Repurposed Drug Candidates for COVID-19.
- Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway.
- Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia.
- Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
- Chemoresistant Cancer Cell Lines Are Characterized by Migratory, Amino Acid Metabolism, Protein Catabolism and IFN1 Signalling Perturbations.
- Lipidomics profiles in hepatocytes from nonalcoholic steatohepatitis patients differ markedly from in vitro-induced steatotic hepatocytes.
- Dimeric Artesunate Glycerophosphocholine Conjugate Nano-Assemblies as Slow-Release Antimalarials to Overcome Kelch 13 Mutant Artemisinin Resistance.
- Red Blood Cell BCL-xL Is Required for Plasmodium falciparum Survival: Insights into Host-Directed Malaria Therapies.
- A new mass spectral library for high-coverage and reproducible analysis of the Plasmodium falciparum-infected red blood cell proteome.
- Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells.
- Dynamic Protein Corona of Gold Nanoparticles with an Evolving Morphology.
- The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite.
- Ultraviolet/Visible and Near-Infrared Dual Spectroscopic Method for Detection and Quantification of Low-Level Malaria Parasitemia in Whole Blood.
- Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity.
- Analytical and Omics-Based Advances in the Study of Drug-Induced Liver Injury.
- Synergy of the Polymyxin-Chloramphenicol Combination against New Delhi Metallo-β-Lactamase-Producing Klebsiella pneumoniae Is Predominately Driven by Chloramphenicol.
- Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines.
- Metabolomes and Lipidomes of the Infective Stages of the Gastrointestinal nematodes, Nippostrongylus brasiliensis and Trichuris muris.
- System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion.
- Measuring Sulforaphane and Its Metabolites in Human Plasma: A High Throughput Method.
- Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa.
- Ozonide Antimalarials Alkylate Heme in the Malaria Parasite Plasmodium falciparum.
- The Development Process for Discovery and Clinical Advancement of Modern Antimalarials.
- Post-Genomic Approaches to Understanding Malaria Parasite Biology: Linking Genes to Biological Functions.
- Discovery and Validation of Clinical Biomarkers of Cancer: A Review Combining Metabolomics and Proteomics.
- 3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity.
- Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa.
- Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa.
- Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.
- Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues.
- Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity.
- Metabolomics-Based Elucidation of Active Metabolic Pathways in Erythrocytes and HSC-Derived Reticulocytes.
- Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments.
- Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action.
