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Gut Microbiota
Dendritic cells
T cells
Antigen presentation
My research focuses on understanding how microbiota-derived metabolites shape immune cell function and influences immune responses. I use a combination of high-throughput screening, cellular immunology and mechanistic approaches to identify microbial metabolites that regulate macrophage, dendritic cell and T cell biology, with the long-term goal of translating these findings into new therapeutic strategies.
Mouse work, flow cytometry, CRISPR, cell biology, functional assays (such as in vivo and in vitro antigen presentation assays and cytokine assays).
I work with a variety of disease models to determine how the gut microbiota influences dendritic cell-T cell activation. This includes viral infection models, such as HSV and LCMV, and tumour models, such as subcutaneous MC38 and B16.
- Lymph nodes fuel KLF2-dependent effector CD8+ T cell differentiation during chronic infection and checkpoint blockade.
- Constitutive Flt3 signaling impacts conventional dendritic cell function.
- CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity.
- Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86.
- MHC Class II Ubiquitination Regulates Dendritic Cell Function and Immunity.
- Ubiquitination of MHC Class II Is Required for Development of Regulatory but Not Conventional CD4+ T Cells.
