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Biochemistry,Structural biology,Molecular biology,Protein chemistry,Infectious diseases
My research work is principally focused on events central to human infection and immunity. Specifically, I work on structural & functional studies on viral and bacterial proteins involved in infection and challenging human immunity. This has important implications for understanding the disease progression in humans and provides hints towards its regulation. My current research also focuses on SARS, HIV and HTLV in understanding host-pathogen interactions. My research key technical areas include X-ray crystallography, cryoEM and cryoET, Molecular dynamics, protein biochemistry and biophysical techniques (SPR, ITC, MALS, SAXS, MST, TPM). I am also an expert in DNA/RNA-Protein interactions and dissecting their functional importance with their physiological role. In particular, in the control of viral RNA replication and translation in humans..
My research key technical areas include X-ray crystallography, Cryo-EM, Cryo-ET, Molecular dynamics, protein biochemistry and biophysical techniques (SPR, ITC, MALS, SAXS, MST, EMSA, TPM) and conduct various cell based assays.
Virus, Mammalian cells, Bacterial cells, computational
- Tetrameric hotdog-fold structure and catalytic mechanism of the SaPaaI thioesterase from Staphylococcus aureus.
- Ligand-Based Pharmacophoric Design and Anti-inflammatory Evaluation of Triazole Linked Semisynthetic Labdane Conjugates.
- Linker-Based Pharmacophoric Design and Semisynthesis of Labdane Conjugates Active against Multi-Faceted Inflammatory Targets.
- Structural Insights into SARS-CoV-2 Nonstructural Protein 1 Interaction with Human Cyclophilin and FKBP1 to Regulate Interferon Production.
- Transcriptional reprogramming by mutated IRF4 in lymphoma.
- Structure of Human TMPRSS2 in Complex with SARS-CoV-2 Spike Glycoprotein and Implications for Potential Therapeutics.
- Structure of the SARS-CoV-2 Nsp1/5'-Untranslated Region Complex and Implications for Potential Therapeutic Targets, a Vaccine, and Virulence.
- Structure of Furin Protease Binding to SARS-CoV-2 Spike Glycoprotein and Implications for Potential Targets and Virulence.
- Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26.
