Dr Seth Masters

Laboratory Head
Inflammation Division
Walter and Eliza Hall Institute of Medical Research

+61 3 9345 2390
masters@wehi.edu.au

Research Activities

Research in the Masters lab is focused on inflammation from the innate immune system. This can happen in many different contexts, for example during a bacterial or virus infection; when cells die during an organ or tissue transplant; or when genetic mutations activate innate immune pathways. The innate immune response is also fundamentally involved in the pathogenesis of many chronic inflammatory diseases like rheumatoid arthritis, Crohns disease and even type 2 diabetes.

Techniques/Expertise

Inflammasome activation
Non apoptotic cell death, eg Pyroptosis and Necroptosis
CRISPR

Collaborations

Prof Luke O'Neill (Trinity College Dublin)
Dr Daniel Kastner (NIH)

Disease Models

Genetic autoinflammatory disease
Infections (Toxo, LCMV, Listeria)
Inflammatory bowel disease
Type 2 diabetes
Asthma

Genetically Modified Organisms

Inflammasome activation mice (NLRP1 and NLRP3)
Inflammasome deficient mice (many eg. Caspase-1, ASC, NLRP3)
Mice lacking cell death genes (many eg Caspase-11)

Other Lab Members

Senior Postdoctoral Fellow:
Motti Gerlic, BSc, PhD Israel
Postdoctoral Fellow:
Man Lyang Kim, BSc, MSc South Korea, PhD Basel
Postgraduate Student:
Paul Baker, BSc(Hons) Adelaide
Undergraduate Student:
Damian D'Silva, BSc RMIT
Katelyn Chalker, BSc Uni Queensland

Other members with similar research interests

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Dr Michelle Tate

Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research SEE FULL PROFILE >

Dr Keith Al-Hasani

Baker IDI Heart and Diabetes Institute SEE FULL PROFILE >

Dr Amy Chung

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

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