Dr Joanna Groom

Laboratory Head
Molecular Immunology
Walter & Eliza Hall Institute of Medical Research

groom@wehi.edu.au

Research Activities

Our immune system requires flexibility to protect us against numerous and varied infectious agents. Following infection, immune cells integrate pathogen-specific signals to promote the dynamic migration and interactions required to determine cell differentiation and function. Our lab investigates multiple mechanisms that work together to direct flexible protective responses.

1. Chemokine control of T cell host defence and memory
2. Diversity in germinal centre (GC) reactions generated by distinct TFH differentiation 
3. Modulation of immune responses by the immunosuppressive chemokines      

Our research combines pathogen models, reporter mice, advanced imaging, and transcriptional analysis to dissect the networks that control cell fate and enable flexibility in immune responses. We use these advanced approaches to identify new therapeutic avenues to drive immune responses either towards protection or away from autoimmunity.    

Techniques/Expertise

Advanced Imaging - 3D whole organ imaging (with clearing), live multi-photon and confocal, Viral models of infection, Transcriptional analysis, Chemokines, Cell migration, T cell-DC interactions, GC biology, MHC II tetramers.

Collaborations

Dr Kim Jacobson
Dr Gabrielle Belz
Laura Mackay
Dr Scott Mueller

Disease Models

Viral Infection models - Influenza, LCMV, HSV-1
Bacterial infection models - Listeria, Toxoplasma

Genetically Modified Organisms

CXCR3 family - reporters and knockouts
Tbx21 floxed
TCR Tgs for LCMV, HSV-I

Other members with similar research interests

prev next

Dr Sidonia Eckle

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Dr Keith Al-Hasani

Baker IDI Heart and Diabetes Institute SEE FULL PROFILE >

Prof Jason Mackenzie

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Upcoming Events

  • Feb 19

    Lorne Infection and Immunity Conference 2020

    150 Mountjoy Parade, Lorne VIC 3232 MORE INFO
  • Feb 20

    19th International Congress on Infectious Diseases

    Kuala Lumpur Convention Centre MORE INFO
  • Feb 27

    Antimicrobials 2020

    Melbourne Exhibition and Convention Centre MORE INFO