Dr Joanna Groom

Laboratory Head
Molecular Immunology
Walter & Eliza Hall Institute of Medical Research

groom@wehi.edu.au

Research Activities

Our immune system requires flexibility to protect us against numerous and varied infectious agents. Following infection, immune cells integrate pathogen-specific signals to promote the dynamic migration and interactions required to determine cell differentiation and function. Our lab investigates multiple mechanisms that work together to direct flexible protective responses.

1. Chemokine control of T cell host defence and memory
2. Diversity in germinal centre (GC) reactions generated by distinct TFH differentiation 
3. Modulation of immune responses by the immunosuppressive chemokines      

Our research combines pathogen models, reporter mice, advanced imaging, and transcriptional analysis to dissect the networks that control cell fate and enable flexibility in immune responses. We use these advanced approaches to identify new therapeutic avenues to drive immune responses either towards protection or away from autoimmunity.    

Techniques/Expertise

Advanced Imaging - 3D whole organ imaging (with clearing), live multi-photon and confocal, Viral models of infection, Transcriptional analysis, Chemokines, Cell migration, T cell-DC interactions, GC biology, MHC II tetramers.

Collaborations

Dr Kim Jacobson
Dr Gabrielle Belz
Laura Mackay
Dr Scott Mueller

Disease Models

Viral Infection models - Influenza, LCMV, HSV-1
Bacterial infection models - Listeria, Toxoplasma

Genetically Modified Organisms

CXCR3 family - reporters and knockouts
Tbx21 floxed
TCR Tgs for LCMV, HSV-I

Other members with similar research interests

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Dr Sidonia Eckle

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Dr Justine Mintern

Department of Biochemistry and Molecular Biology University of Melbourne SEE FULL PROFILE >

Prof Colby Zaph

Department of Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

Upcoming Events

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    Student Open Day Hudson Institute of Medical Research

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    Student Open Day Walter and Eliza Hall Institute

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  • Sep 10

    Student Open Day Walter and Eliza Hall Institute

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