Prof Sharon Lewin

Director
Peter Doherty Institute
University of Melbourne

sharon.lewin@unimelb.edu.au

Contract research opportunities

  • HIV viral isolation and culture for clinical and basic research
  • Quantification of HIV viral RNA and DNA in patient samples
  • Establishing and maintaining prospective clinical cohorts
  • PBMC isolation and storage using leukapharesis
  • Lymph node biopsy …
    and cell extraction
  • Specialised flow cytometry
SEE MORE DETAIL | EMAIL ENQUIRY >

Latest News

  • In January 2019, Professor Lewin was appointed as an Officer in the Order of Australia Awards on Australia Day
  • Professor Lewin was re-appointed as Chair, Health Translation Advisory Committee for the National Health and Medical Research Council (2019-222) and member of the Governing Council of the NHMRC

Research Activities

Professor Sharon Lewin is the inaugural Director of the Doherty Institute for Infection and Immunity, a joint venture between the University of Melbourne and Melbourne Health (Royal Melbourne Hospital) and Professor of Medicine, The University of Melbourne. Professor Lewin is an infectious diseases physician and basic scientist. She is a consultant physician and Adjunct Professor with the Department of Infectious Diseases, Monash University and Alfred Hospital, and an NHMRC Practitioner Fellow.

Professor Lewin's laboratory focuses on both clinical trials and laboratory based pathogenesis studies. Her laboratory investigates the mechanisms of why HIV persists on antiretroviral therapy and the development of latency reversing and silencing agents. She is the principal investigator of multiple novel early phase clinical trials to eliminate latency.

Her laboratory has also had a long standing interest in hepatitis B virus and HIV-HBV co-infection, understanding accelerated liver disease in HIV-HBV co-infection and understanding the immune response to HBV.

Techniques/Expertise

  • Clinical trials 
  • HIV viral culture, quantification, infection 
  • In vitro models of HIV latency 
  • Analysis ex vivo of patient cells collected by leukopharesis and lymph node biopsy
  • Multiparameter flow cytometry including high speed cell sorting 
  • Quantification of virus persistence on ART including PCR based assays and culture
  • Integration site analyses
  • HBV in vitro models 
  • Establishing and maintaining prospective clinical cohorts

Collaborations

HIV (National):
A/Prof Melissa Churchill (Burnet Inst, Melbourne)
Dr Lachlan Gray
Professor Suzanne Crowe AM
A/Prof Anthony Jaworowski
Prof Stephen Kent
Prof Damian Purcell (Doherty Inst, University of Melbourne)
A/Prof Edwina Wright (Monash Uni, Alfred Health, Melbourne)
Dr Julian Elliott (Monash Uni, Alfred Health, Melbourne)
Prof Jennifer Hoy (Monash Uni, Alfred Health, Melbourne)
Prof Paul Gorry (RMIT, Melbourne)
Prof Johnson Mak (Deakin CSIRO, Geelong)
A/Prof Sarah Palmer (Westmead Millenium Inst, Sydney)
Prof Tony Cunningham (Westmead Millenium Inst, Sydney)
Prof Graeme Stewart (Westmead Millenium Inst, Sydney)
A/Prof David Booth (Westmead Millenium Inst, Sydney)
Prof Miles Davenport (University of NSW, Sydney)
Prof Martyn French (University of Western Australia, Perth)
Professor Simon Mallal (Murdoch University, Perth)
A/Prof Di Yu (Monash University)
HIV (International):
Prof Steve Deeks (UCSF, San Fransisco, USA)
Prof Mike McCune (UCSF, San Francisco, USA)
Dr Afam Okoye (Oregon Health Sciences Univ, Portland, USA)
Dr Jake Estes (National Cancer Inst, Frederick, USA)
Dr Jeff Lifson (National Cancer Inst, Frederick, USA)
Dr Richard Barnard (Merck, West Point, USA)
Dr Nicolas Chomont (U. Montreal, Montreal, Canada)
Dr Remi Fromentin (U. Montreal, Montreal, Canada)
Dr Thomas Rasmussen (Aarhus Uni, Aarhus, Denmark)
A/Prof Martin Tolstrup (Aarhus Uni, Aarhus, Denmark)
Prof Lars Ostergaard (Aarhus Uni, Aarhus, Denmark)
Dr Timothy Henrich (Brigham and Women's Hospital, Cambridge, UK)
Prof Philip Goulder (U. Oxford, London, UK)
Prof Thumbi Ndungu (U. of KwaZulu-Natal, Durban, South Africa)
Dr Reena Rajasuriar (U. Malaya, Kuala Lumpur, Malaysia)
Adeeba Kamarulzaman (U. Malaya, Kuala Lumpur, Malaysia)
Dr Jintanat Ananworanich (US Military HIV Research Program, Bethesda, USA)
Dr Leslie Cockerham (Medical College of Wisconsin, USA)
HBV (National):
Prof Stephen Locarnini (VIDRL, Royal Melbourne Hospital at the Doherty Institute, Melbourne)
Dr Scott Bowden (VIDRL, Royal Melbourne Hospital at the Doherty Institute, Melbourne)
Dr Joe Sasadeusz (VIDS, Royal Melbourne Hospital at the Doherty Institute, Melbourne)
HBV (International):
Dr Anchalee Avahingsanon (HIV Netherlands Australia Thailand Collaboration, Thai Red Cross, Bangkok, Thailand)
A/Prof Kiat Ruxrungtham (HIV Netherlands Australia Thailand Collaboration, Thai Red Cross, Bangkok, Thailand)
Dr Chloe Thio (Johns Hopkins, Baltimore, USA)
Dr Angela Kashuba (University of North Carolina, Durham, NC)
Dr Jake Estes (National Cancer Institute, Frederick, MD)
Industry:
Richard Barnard and Daria Hazuda, Merck
David Favre, GSK
Fraser Drummond, Viiv Healthcare

Disease Models

HIV Latency
HIV-HBV co-infection
DC-T-cell models

Other Lab Members

Laboratory Head:
Prof Sharon Lewin
Senior Scientists:
Dr Thomas Rasmussen (Associate Clinical Director, HIV Cure studies)
Ajantha Rhodes (Clinical Operations Manager & Laboratory Manager; Head, Virology Core)
Dr Judy Chang (Research Systems Administrator - Clinical Research; Head, Immunology Core)
Dr Jenny Anderson (Senior Research Fellow - Virology)
Dr Jennifer Audsley (Senior Research Fellow – Clinical Research)
Dr Michael Roche (Part time senior research fellow and Senior Lecturer, RMIT)
Post-doctoral Fellows:
Dr Jori Symons (Post-doctoral Research Fellow)
Dr Wei Zhao (Post-doctoral Research Fellow)
Dr Jennifer Zerbato (Post-doctoral Research Fellow)
Dr Chris Chiu (Post-doctoral Research Fellow)
Dr Celine Gubser (Post-doctoral Research Fellow)
Research Assistants:
Surekha Tennakoon (Research Assistant)
Ashanti Dantanarayana (Research Assistant)
Socheata Chea (Research Assistant)
Charlene Mackenzie (Research Assistant)
PhD Students (Uni Melb):
Dr Matthew Pitman (Clinician researcher)
Ms Youry Kim
Ms Zuwena Richardson
Ms Rachel Pascoe
Ms Paula Cevaal
Mr Haoming Liu
Mr Jared Stern
Mr Abdalla Ali
PhD Students (Monash):
Dr Kasha Singh (Clinician researcher)
Dr Jill Lau (Clinician researcher)
Visiting/Honorary Clinician Scientists:
Associate Professor Paul Cameron
Associate Professor Edwina Wright
Associate Professor Joe Sasadeusz
Dr James McMahon
Dr Christoph Coch (sabbatical visitor, University of Bonn)
Research support staff:
Dr Jasminka Sterjovski (Research Manager)
Dr Amanda Brass (HIV Cure Program Manager)
Barb Scher (Clinical Trials Liaison Officer)

Other members with similar research interests

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Prof Jason Mackenzie

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

A/Prof Margaret Hellard

Centre for Population Health Burnet Institute SEE FULL PROFILE >

Mr Albert Garcia Minambres

School of Medicine Deakin University SEE FULL PROFILE >

Upcoming Events

  • Feb 19

    Lorne Infection and Immunity Conference 2020

    150 Mountjoy Parade, Lorne VIC 3232 MORE INFO
  • Feb 20

    19th International Congress on Infectious Diseases

    Kuala Lumpur Convention Centre MORE INFO
  • Feb 27

    Antimicrobials 2020

    Melbourne Exhibition and Convention Centre MORE INFO