Prof Stephen Kent

Laboratory Head
Department of Microbiology and Immunology
University of Melbourne

skent@unimelb.edu.au

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Contract research opportunities

Immunity studies in HIV and Influenza. We have worked with major pharmaceutical groups to evaluate aspects of vaccine-induced immunity in both humans and non-human primates.
rimates.
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Research Activities

An HIV vaccine is urgently needed and improved vaccines against influenza are needed. The Kent lab is working towards these goals. A better understanding of effective immunity will expand the pipeline to novel treatment and prevention strategies.

Current projects:
  • ADCC responses to HIV and Influenza
  • B cell responses to Influenza
  • Immune escape from H/SIV and Influenza
  • Germinal Centre B cells and Tfh cells in H/SIV and influenza
  • Nanoparticle vaccines
  • NKT, MAIT cells and CD1-restricted T cells and H/SIV
  • Influenza-HIV vaccines

Techniques/Expertise

To further understand how immune responses can control HIV, we have developed multiple assays to measure immunity and the effect these immune responses have on the virus. We recently developed new techniques to measure antibody dependent cellular cytotoxicity (ADCC). We developed a very simple assay on small volumes of blood to measure ADCC responses and are now studying how useful it is in people with HIV and whether it forces the virus to mutate to escape this potentially important response. Although T cell immunity is effective against the virus, immune escape is a hallmark of effective T cell immunity.  

Collaborations

Dr Damian Purcell, University of Melbourne
Dr Rob Center
Dr Miles Davenport, University of NSW
Dr Dale Godfrey, University of Melbourne
Dr Andrew Brooks, University of Melbourne
Dr Frank Caruso, University of Melbourne
ARC Centre of Excellence in Bio-Nano Science
NHMRC program grant on HIV
WHO centre for Influenza

Disease Models

Primate models of HIV/SIV and Influenza
Mouse and ferret models of HIV and influenza vaccination
Human clinical trials of HIV and Influenza immunity

Genetically Modified Organisms

MHC-defined primates

Other Lab Members

Ms Sheilajen Alcantara (Technical Assistant)
Ms Thakshila Amarasena (Technical Assisant)
Dr Amy Chung
Dr Adam Wheatley
Dr Jane Batten (Research support)
Mr Yi Liu, PhD student
Mr Timon Damelang, PhD Student
Ms Robyn Esterbauer, Research Assistant
Ms Ester Lopez, Research Assistant
Ms Kathleen Wragg, Research Assistant
Dr Hyon-Xhi Tan
Dr Jennifer Juno
Ms Hannah Kelly, PhD student
Dr Isaac Barber-Axthelm, PhD student
Dr Wen Shi Lee
Dr Kevin John Selva
Dr Wingyang Wang
Ms Sriveni Pantham (Technical assistant)
Ms Hannah Kelly, PhD student
Mr Julius Wong, PhD student
Mr Wenbo Jiang, PhD student
Ms Samantha Davis, PhD student
Ms Mai Vu, PhD student

Research Images

Other members with similar research interests

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Prof Phil Sutton

Infection and Immunity Theme Murdoch Childrens Research Institute SEE FULL PROFILE >

Dr Brad Sleebs

Chemical Biology The Walter and Eliza Hall Institute SEE FULL PROFILE >

Associate Professor Di Yu

Department of Immunology Monash University SEE FULL PROFILE >

Upcoming Events

  • Jun 3

    7th International Symposium on Antimicrobial Peptides (AMP2020)

    Institut Pasteur MORE INFO
  • Jun 3

    Australasian Society for Infectious Diseases (ASID) Annual Scientific Meeting 2020

    Pullman Melbourne on the Park MORE INFO
  • Jun 3

    Impact of Environmental Changes on Infectious Diseases (IECID) 2020

    James Cook University, Singapore