Prof Stephen Kent

Laboratory Head
Department of Microbiology and Immunology
University of Melbourne

skent@unimelb.edu.au

Contract research opportunities

Immunity studies in HIV and Influenza. We have worked with major pharmaceutical groups to evaluate aspects of vaccine-induced immunity in both humans and non-human primates.
rimates.
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Research Activities

An HIV vaccine is urgently needed. The Kent lab is working towards this goal. Better vaccine strategies are needed to prevent HIV infection and disease. This requires an understanding of how HIV causes AIDS, including which immune responses control HIV replication and which contribute to disease. A better understanding of effective immunity will expand the pipeline to novel treatment and prevention strategies.

Current projects:
  • ADCC responses to HIV and Influenza
  • B cell responses to Influenza
  • Immune escape from H/SIV
  • Env-specific T cells
  • Treg cells and H/SIV
  • Nanoparticle vaccines
  • NKT, MAIT cells and CD1-restricted T cells and H/SIV
  • Influenza-HIV vaccines

Techniques/Expertise

To further understand how immune responses can control HIV, we have developed multiple assays to measure immunity and the effect these immune responses have on the virus. We recently developed new techniques to measure antibody dependent cellular cytotoxicity (ADCC). We developed a very simple assay on small volumes of blood to measure ADCC responses and are now studying how useful it is in people with HIV and whether it forces the virus to mutate to escape this potentially important response. Although T cell immunity is effective against the virus, immune escape is a hallmark of effective T cell immunity.  

Collaborations

Drs David Cooper, Andrew Lloyd, Greg Dore, Anthony Kelleher, Sean Emery University of NSW
Dr Martyn French, University of Western Australia
Dr Damian Purcell, University of Melbourne
Dr Rob Center
Dr Miles Davenport, University of NSW
Dr Dale Godfrey, University of Melbourne
Dr Andrew Brooks, University of Melbourne
Dr Frank Caruso, University of Melbourne
ARC Centre of Excellence in Bio-Nano Science
NHMRC program grant on HIV

Disease Models

Primate models of HIV/SIV and Influenza
Mouse models of HIV and OVA vaccination
Human clinical trials of HIV and Influenza immunity

Genetically Modified Organisms

MHC-defined primates

Other Lab Members

Ms Sheilajen Alcantara (Technical Assistant)
Ms Thakshila Amarasena (Technical Assisant)
Ms Megan Schepers (Animal Technician)
Dr Matthew Parsons
Mr Wen Shi Lee, PhD student
Dr Amy Chung
Dr Adam Wheatley
Dr Jane Batten (Research support)
Mr Yi Liu, PhD student
Ms Anne Kristensen, Research Assistant
Ms Hillary Vanderven, PhD student
Mr Matthew Worley, PhD Student
Mr Kevin Selva, PhD Student
Mr Timon Damelang, PhD Student
Ms Robyn Esterbauer, Research Assistant
Ms Ester Lopez, Research Assistant
Ms Kathleen Wragg, Research Assistant
Dr Hyon-Xhi Tan
Dr Jennifer Juno
Ms Hannah Kelly, PhD student

Research Images

Other members with similar research interests

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Mr Dhanasekaran Sakthivel

Department of Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

A/Prof Aeron Hurt

WHO Collaborating Centre for Reference and Research on Influenza SEE FULL PROFILE >

Dr Gabrielle Belz

Molecular Immunology Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Upcoming Events

  • Dec 2

    ASI 2018

    Pan Pacific Hotel MORE INFO
  • Dec 2

    10th HKU-Pasteur Immunology Course

    MORE INFO
  • Feb 20

    Lorne Infection and Immunity Conference 2019

    Cumberland Lorne Resort MORE INFO