Prof Jian Li

NHMRC PRF
Monash Institute of Pharmaceutical Sciences
Monash University

jian.li@monash.edu

Research Activities

Pharmacokinetics and pharmacodynamics of polymyxins against multidrug-resistant 'superbugs', in particular Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae (NHMRC and NIH funded projects)
Mechanisms of activity and resistance of polymyxins (NIH and NHMRC funded projects)
Discovery of novel lipopeptides and natural products against Gram-negative polymyxin-resistant 'superbugs' (NIH and NHMRC funded projects)
Combination of antimicrobial agents (NHMRC and NIH funded projects)
Chemotherapy for infections in patients with cystic fibrosis
Novel anti-pathogenic agents
Integration of pharmacokinetic and pharmacodynamic principles to assist in antimicrobial development, to reduce resistance development and to optimize efficacy in the clinical use of antimicrobial agents
Lead optimisation of new antimicrobial entitiesPhage pharmacology and therapy

Techniques/Expertise

Susceptibility testing including: minimum inhibitory and bactericidal concentrations; fractional inhibition concentrations (for combinations); population analysis profiles
Time-kill experiments and post-antibiotic effect experiments (in vitro and in vivo)
In vitro Pharmacokinetic/Pharmacodynamic (PK/PD) infection model
In vitro biofilm model
Animal infection models (mouse thigh and mouse lung)
Quantitative analysis of drugs in biological fluids (using HPLC, LC/MS and bioassays) Pharmacokinetics of antimicrobials in small animals, including hepatic and renal handling of drugs and metabolites
Structure-activity relationships of polymyxin peptides against Gram-negative pathogens
Discovery and purification of novel antimicrobial agents from natural products

Collaborations

Professor John Turnidge (Women's and Children's Hospital)
Professor David Paterson (Royal Brisbane and Women's Hospital)
Associate Professor Denis Spelman (Alfred Hospital)
Professor Jeff Lipman (University of Queensland)
Drs Ian Larson, Tony Velkov, Phil Thompson, Jamie Simpson, Ben Boyd, David Morton, Richard Prankerd, Michelle McIntosh and Prof Chris Porter (Monash Institute of Pharmaceutical Sciences, Monash University)
Dr Alexandre Prehn Zavascki (Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul, Brazil)
Professor Yue-zhong Li (Shandong University, China)
Prof Roger Nation
Dr Marina Harper
Prof Brian Tsuji (USA)
Prof John Boyce
Prof Ben Howden

Disease Models

Mouse thigh infection model
Mouse lung infection modelMouse bloodstream infection modelMouse UTI infection modelMouse wound infection modelMouse and rat pharmacokinetics models

Other members with similar research interests

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A/Prof Jan Tennent

Biomedical Research Victoria SEE FULL PROFILE >

Prof Jason Mackenzie

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Dr Yogitha Srikhanta

Microbiology Monash Univserity SEE FULL PROFILE >

Upcoming Events

  • Oct 9

    DC2022: 16th International Symposium on Dendritic Cells 2022

    Pullman Cairns International REGISTER | MORE INFO
  • Nov 16

    VIIN Young Investigator Symposium 2022

    Monash Institute of Pharmaceutical Sciences MORE INFO
  • Dec 4

    11th Annual Conference of the International Chemical Biology Society

    Brisbane Conference & Exhibition Centre MORE INFO