Prof Alex Andrianopoulos

Laboratory Head
School of BioSciences
University of Melbourne

alex.a@unimelb.edu.au

Research Activities

We are studying a number of aspect of T. marneffei biology and pathogenicity and are particularly interested in understanding the molecular mechanisms which control the dimorphic switching and asexual development (conidiation) programs. Dimorphic switching is a temperature- and host-dependent response that allows T. marneffei to switch from a non-pathogenic hyphal growth form to the pathogenic yeast form. The yeast form is specialized to survive with host innate immune cells. Asexual development is the program the produce asexual spores, the infectious particles. We are teasing up the mechanisms that control these programs and examining their effects on growth and pathogenesis in the host.

Techniques/Expertise

DNA-protein interactions, genomics, transcriptomics

Disease Models

Macrophage cells, zebrafish, mice

Genetically Modified Organisms

Talaromyces marneffei (formerly Penicillium marneffei), Aspergillus fumigatus, Aspergillus nidulans

Other members with similar research interests

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Prof Roger Nation

Monash Institute of Pharmaceutical Sciences Monash University SEE FULL PROFILE >

Prof Bill Heath

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Prof Phil Sutton

Infection and Immunity Theme Murdoch Childrens Research Institute SEE FULL PROFILE >

Upcoming Events

  • Feb 27

    Antimicrobials 2020

    Melbourne Exhibition and Convention Centre MORE INFO
  • Mar 6

    Australasian Bone and Joint Infection Conference

    MORE INFO
  • Mar 15

    2020 Antibody Biology and Engineering Gordon Research Conference

    Ventura Beach Marriott MORE INFO