Dr Aaron Irving

Postdoctoral Fellow
Emerging Infectious Diseases
Duke-NUS Medical School

aaron.irving@duke-nus.edu.sg

Research Activities

Pattern recognition receptors and activation of innate immunity and inflammasome.
Viral infection and innate immunity.
Differences in innate immune activation and inflammasome sensing between bats and humans.

Techniques/Expertise

Mammalian cell culture (epithelial cells, bone marrow derived macrophages/dcs, macrophage lines, T cell lines, PBMCs, lung, liver, kidney, whole splenocytes)
Immuno-detection techniques (eg. ELISA, Western blotting, flow cytometry)
inflammasome activation
NGS and proteomics
TLR ligand screening
Gene knockdown (RNAi)
Confocal and live-cell microscopy
Molecular Biology (cloning, mutagenesis, library screening)
Viral infection assays (NBV, HeV, SeV, MuV, Zika, DV, SFV, Adv5, HSV1, EMCV, RSV, VZV)
Cellular movement (cellular migration, phagocytic uptake)

Disease Models

inflammasome
virus infections

Genetically Modified Organisms

mice
bat (KO cells)

Other Lab Members

Linfa wang

Other members with similar research interests

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Ms Julia Prier

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Dr Scott Mueller

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Dr Raffi Gugasyan

Centre for Biomedical Research Burnet Institute SEE FULL PROFILE >

Upcoming Events

  • Mar 24

    World Tuberculosis Day

  • Apr 13

    29th European Congress of Clinical Microbiology & Infectious Diseases

    MORE INFO
  • Apr 25

    World Malaria Day