Dr Aaron Irving

Postdoctoral Fellow
Emerging Infectious Diseases
Duke-NUS Medical School

6565 767 082
aaron.irving@duke-nus.edu.sg

Research Activities

Pattern recognition receptors and activation of innate immunity and inflammasome.
Viral infection and innate immunity.
Differences in innate immune activation and inflammasome sensing between bats and humans.

Techniques/Expertise

Mammalian cell culture (epithelial cells, bone marrow derived macrophages/dcs, macrophage lines, T cell lines, PBMCs, lung, liver, kidney, whole splenocytes)
Immuno-detection techniques (eg. ELISA, Western blotting, flow cytometry)
inflammasome activation
NGS and proteomics
TLR ligand screening
Gene knockdown (RNAi)
Confocal and live-cell microscopy
Molecular Biology (cloning, mutagenesis, library screening)
Viral infection assays (NBV, HeV, SeV, MuV, Zika, DV, SFV, Adv5, HSV1, EMCV, RSV, VZV)
Cellular movement (cellular migration, phagocytic uptake)

Disease Models

inflammasome
virus infections

Genetically Modified Organisms

mice
bat (KO cells)

Other Lab Members

Linfa wang

Other members with similar research interests

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A/Prof John Stambas

School of Medicine Deakin University SEE FULL PROFILE >

Mr Adam Lopez-Denman

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Prof Michael Hickey

Department of Medicine - Monash Medical Centre Monash University SEE FULL PROFILE >

Upcoming Events

  • Jun 14

    Opening Symposium of the Jeffrey Modell Foundation Centre for Primary Immunodeficiencies Melbourne

    REGISTER | MORE INFO
  • Jun 22

    IgV Winter Seminar

  • Jun 28

    Asia Pacific AIDS & Co-infections Conference (APACC)

    Hong Kong Convention & Exhibition Centre MORE INFO