A/Prof Aaron Irving

Group Leader
ZJU-UoE Institute,
Zhejiang University School of Medicine

aaronirving@intl.zju.edu.cn

Licensing opportunities

serology



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Research Activities

Pattern recognition receptors and activation of innate immunity and the inflammasome.
Viral infection and innate immunity, Host-pathogen interactions.
Differences in innate immune activation and inflammasome sensing between bats and humans and applications to human health - comparative immunology.

Techniques/Expertise

Mammalian cell culture (epithelial cells, bone marrow derived macrophages/dcs, macrophage lines, T cell lines, PBMCs, lung, liver, kidney, whole splenocytes)
Immuno-detection techniques (eg. ELISA, Western blotting, flow cytometry)
inflammasome activation
NGS and proteomics
TLR ligand screening
Gene knockdown (RNAi)
Confocal and live-cell microscopy
Molecular Biology (cloning, mutagenesis, library screening)
Viral infection assays (NBV, HeV, SeV, MuV, Zika, DV, SFV, Adv5, HSV1, EMCV, RSV, VZV)
Cellular movement (cellular migration, phagocytic uptake)

Disease Models

inflammasome
virus infections
primary cells
primary bat cells
in vivo bat infections
MERS-CoV, SARS-CoV-2, PRV, IAV, HSV, DENV, ZIKV, bat IAVs

Genetically Modified Organisms

mice
bat (KO cells)

Other members with similar research interests

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Dr Mithun Das

Zoonotic Disease Platform Team The Commonwealth Scientific and Industrial Research Organisation (CSIRO) SEE FULL PROFILE >

Dr Naveen Vankadari

Department of Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

A/Prof Motti Gerlic

Clinical microbiology & immunology, Sackler medical school Tel Aviv University SEE FULL PROFILE >

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