A/Prof Ashley Mansell

Laboratory Head
Centre for Innate Immunity and Infectious Diseases
Hudson Institute of Medical Research

ashley.mansell@hudson.org.au

"Through the Lorne Infection and Immunity meeting, I met the CEO of a US based Biotech startup and began conducting contract research on their behalf. Through this, we developed a novel inflammasome inhibitor and I have now joined this company called Adiso Therapeutics as Head of Translational Sciences while also maintaining my laboratory and adjunct position at Hudson Institute."

Research Activities

Pattern Recognition Receptors based research investigating:
  • The Toll-like receptor (TLRs), RIG-like Helicase (RLHs) and NOD-like receptors (NLRs)
  • Signal transduction pathways initiated upon recognition of both pathogen and endogenous TLR ligands
  • Structure/Function analysis of TLR signaling mediators
  • Negative regulation of these pathways to prevent chronic inflammation
  • Pathogen immunomodulation of these pathways/receptors

Techniques/Expertise

activation of NF-kB and IFNγ by various means
cell biology
TLR screening
Viral infections
TLR expressing cell lines
TLR/PRR/Signaling pathway
immortalized gene-deficient BMMs
Inflammasome Imaging

Collaborations

Luke O'Neill, Trinity College Dublin
Katherine Fitzgerald, University of Massachusetts
Eicke Latz, University of Bonn
A/Prof Richard Ferrero
Prof Brendan Jenkins
Dr Michelle Tate

Disease Models

Septic Shock
Viral Infection
Inflammasome
Influenza A virus
E. coli
Silicosis

Genetically Modified Organisms


ASC-/-
NLRP3-/-

Research Images

Other members with similar research interests

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Prof Elizabeth Hartland

Hudson Institute of Medical Research SEE FULL PROFILE >

Prof Jason Mackenzie

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Dr Kristie Jenkins

Australian Animal Health Laboratory CSIRO SEE FULL PROFILE >

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