Dr Seth Masters

Laboratory Head
Inflammation Division
Walter and Eliza Hall Institute of Medical Research

masters@wehi.edu.au

Research Activities

Research in the Masters lab is focused on inflammation from the innate immune system. This can happen in many different contexts, for example during a bacterial or virus infection; when cells die during an organ or tissue transplant; or when genetic mutations activate innate immune pathways. The innate immune response is also fundamentally involved in the pathogenesis of many chronic inflammatory diseases like rheumatoid arthritis, Crohns disease and even type 2 diabetes.

Techniques/Expertise

Inflammasome activation
Non apoptotic cell death, eg Pyroptosis and Necroptosis
CRISPR

Collaborations

Prof Luke O'Neill (Trinity College Dublin)
Dr Daniel Kastner (NIH)

Disease Models

Genetic autoinflammatory disease
Infections (Toxo, LCMV, Listeria)
Inflammatory bowel disease
Type 2 diabetes
Asthma

Genetically Modified Organisms

Inflammasome activation mice (NLRP1 and NLRP3)
Inflammasome deficient mice (many eg. Caspase-1, ASC, NLRP3)
Mice lacking cell death genes (many eg Caspase-11)

Other Lab Members

Senior Postdoctoral Fellow:
Motti Gerlic, BSc, PhD Israel
Postdoctoral Fellow:
Man Lyang Kim, BSc, MSc South Korea, PhD Basel
Postgraduate Student:
Paul Baker, BSc(Hons) Adelaide
Undergraduate Student:
Damian D'Silva, BSc RMIT
Katelyn Chalker, BSc Uni Queensland

Other members with similar research interests

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Ms Caitlin Rowe

Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

Dr Rebecca Gorrell

Department of Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

Dr Prasad Paradkar

Health and Biosecurity CSIRO SEE FULL PROFILE >

Upcoming Events

  • Aug 31

    The Inaugural Melbourne Immunotherapy Network Winter Retreat

    Vibe Hotel, Marysville MORE INFO
  • Sep 14

    ASID & ESCMID Perinatal Infectious Diseases Workshop 2018

    Q-Station MORE INFO
  • Oct 18

    VIIN Young Investigator Symposium 2018

    Walter and Eliza Hall Institute MORE INFO