Dr Seth Masters

Laboratory Head
Inflammation Division
Walter and Eliza Hall Institute of Medical Research

masters@wehi.edu.au

Research Activities

Research in the Masters lab is focused on inflammation from the innate immune system. This can happen in many different contexts, for example during a bacterial or virus infection; when cells die during an organ or tissue transplant; or when genetic mutations activate innate immune pathways. The innate immune response is also fundamentally involved in the pathogenesis of many chronic inflammatory diseases like inflammatory bowel disease, type 2 diabetes, and neuroinflammatory conditions.

Techniques/Expertise

Inflammasome activation
Non apoptotic cell death, eg Pyroptosis and Necroptosis
CRISPR

Collaborations

Prof Luke O'Neill (Trinity College Dublin)
Dr Daniel Kastner (NIH)

Disease Models

Genetic autoinflammatory disease
Infections (Toxo, LCMV, Listeria)
Inflammatory bowel disease
Type 2 diabetes
Neuroinflammation

Genetically Modified Organisms

Inflammasome activation mice (NLRP1 and NLRP3)
Inflammasome deficient mice (many eg. Caspase-1, ASC, NLRP3)
Mice lacking cell death genes (many eg Caspase-11)

Other Lab Members

Senior Postdoctoral Fellow:
Motti Gerlic, BSc, PhD Israel
Postdoctoral Fellow:
Man Lyang Kim, BSc, MSc South Korea, PhD Basel
Postgraduate Student:
Paul Baker, BSc(Hons) Adelaide
Undergraduate Student:
Damian D'Silva, BSc RMIT
Katelyn Chalker, BSc Uni Queensland

Other members with similar research interests

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Dr Gabrielle Belz

Molecular Immunology Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Prof Bryan Williams

Hudson Institute of Medical Research SEE FULL PROFILE >

Prof Brian Cooke

Department of Microbiology Monash University SEE FULL PROFILE >

Upcoming Events

  • Jun 2

    15th Symposium of the International Society of Vascular Infectious Diseases

    MORE INFO
  • Jun 3

    17th International TNF Superfamily Conference

    Asilomar Conference Grounds, 800 Asilomar Ave, Pacific Grove, CA 93950 MORE INFO
  • Jun 13

    VIIN Careers Evening 2019

    Burnet Institute MORE INFO