Dr Seth Masters

Laboratory Head
Inflammation Division
Walter and Eliza Hall Institute of Medical Research

masters@wehi.edu.au

Research Activities

Research in the Masters lab is focused on inflammation from the innate immune system. This can happen in many different contexts, for example during a bacterial or virus infection; when cells die during an organ or tissue transplant; or when genetic mutations activate innate immune pathways. The innate immune response is also fundamentally involved in the pathogenesis of many chronic inflammatory diseases like inflammatory bowel disease, type 2 diabetes, and neuroinflammatory conditions.

Techniques/Expertise

Inflammasome activation
Non apoptotic cell death, eg Pyroptosis and Necroptosis
CRISPR

Collaborations

Prof Luke O'Neill (Trinity College Dublin)
Dr Daniel Kastner (NIH)

Disease Models

Genetic autoinflammatory disease
Infections (Toxo, LCMV, Listeria)
Inflammatory bowel disease
Type 2 diabetes
Neuroinflammation

Genetically Modified Organisms

Inflammasome activation mice (NLRP1 and NLRP3)
Inflammasome deficient mice (many eg. Caspase-1, ASC, NLRP3)
Mice lacking cell death genes (many eg Caspase-11)

Other Lab Members

Senior Postdoctoral Fellow:
Motti Gerlic, BSc, PhD Israel
Postdoctoral Fellow:
Man Lyang Kim, BSc, MSc South Korea, PhD Basel
Postgraduate Student:
Paul Baker, BSc(Hons) Adelaide
Undergraduate Student:
Damian D'Silva, BSc RMIT
Katelyn Chalker, BSc Uni Queensland

Other members with similar research interests

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Dr Maria Liaskos (Kaparakis-Liaskos)

Department of Physiology, Anatomy and Microbiology La Trobe University SEE FULL PROFILE >

Dr Thomas Angelovich

School of Health and Biomedical Sciences RMIT University SEE FULL PROFILE >

Prof Bill Heath

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Upcoming Events

  • Feb 20

    Lorne Infection and Immunity Conference 2019

    Cumberland Lorne Resort MORE INFO
  • Sep 15

    14th World Congress of Inflammation

    MORE INFO
  • Feb 19

    Lorne Infection and Immunity Conference 2020

    150 Mountjoy Parade, Lorne VIC 3232 MORE INFO