Dr Ashraful Haque
QIMR Berghofer Medical Research Ins
We have demonstrated that Type I IFN signalling impairs CD4+ T helper 1 responses in mice infected with blood-stage Plasmodium parasites. This immunological suppression acts on conventional dendritic cells in the spleen, and serves to impair parasite control.
Research ActivitiesWe research the interactions that occur between the malaria-causing parasite, Plasmodium, and cells of the mammalian immune system. Symptoms of malaria in humans occur after the parasite infects red blood cells, with severe, and fatal disease often occurring in patients with the largest numbers of parasites in their bodies.Our aim is to understand how infected red blood cells can be detected and cleared from the body by the immune system, and importantly, why this process so often fails. We research novel strategies for improving parasite clearance, to inform the development of better vaccines and immune-therapies against malaria.
Techniques/ExpertiseOur approach has been to generate new tools and techniques to study Plasmodium parasites in well-established experimental malaria models. We are currently focused on understanding how Plasmodium interactions with dendritic cells and macrophages controls both the outcome of infection, and the onset of adaptive immunity to malaria.
Disease Modelsmurine blood-stage malaria models
Other Lab MembersKylie R James