Dr Niamh Mangan

Senior Research Officer
Centre for Innate Immunity and Infectious Diseases
Hudson Institute of Medical Research

niamh.mangan@hudson.org.au

Research Activities

Dr Mangan is a research scientist and emerging expert in immunology of infections and inflammation. Her research interests lie primarily in understanding cellular mechanisms of modulation and suppression of the immune response in infections and inflammation. Her current research examines the role of interferon, cytokine and receptor signaling in immune regulation, in particular characterising the novel cytokine interferon epsilon (IFNe) in the regulation of mucosal immune responses.

Techniques/Expertise

Characterising cell types of low frequency e.g. innate-like immune cells in mucosal organs including the reproductive tract, the skin and the lungs.
Phenotyping of transgenic/knockout mouse models of type 1 and 2 immune responses in infection and inflammation.
16 colour flow cytometry
Cytokine bead arrays, ELISA
Human and mouse primary mucosal epithelial cell preparations
RNA analysis: RT-PCR, microarray, Fluidigm

Collaborations

Dr Michael Gantier
Dr Marcel Nold
Dr Claudia Nold
Prof Luke O'Neill
Prof James McCluskey
Dr Gabrielle Belz
Dr Lisa Mielke
Dr Aaron Irving
Prof Caroline Gargett
Dr Jemma Evans
Prof Phil Hansbro
Dr Jay Horvat
Prof Paul Hertzog

Disease Models

Experimental mouse models of reproductive tract infections - Herpes Simplex Virus 2, Candida albicans or Chlamydia muridarum.
Influenza virus lung infections
Colitis models- Dextran sodium sulphate

Other members with similar research interests

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Miss Shan Huang

Department of Physiology, Anatomy and Microbiology La Trobe University SEE FULL PROFILE >

Dr Tom Brodnicki

Immunology and Diabetes Unit St Vincents Institute SEE FULL PROFILE >

Prof Julian Rood

Department of Microbiology Monash University SEE FULL PROFILE >

Upcoming Events

  • Jun 3

    7th International Symposium on Antimicrobial Peptides (AMP2020)

    Institut Pasteur MORE INFO
  • Jun 3

    Australasian Society for Infectious Diseases (ASID) Annual Scientific Meeting 2020

    Pullman Melbourne on the Park MORE INFO
  • Jun 3

    Impact of Environmental Changes on Infectious Diseases (IECID) 2020

    James Cook University, Singapore