Dr Ben Croker

Associate Professor
Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, School of Medicine, UCSD Center for Immunity, Infection, and Inflammation
University of California, San Diego

bcroker@ucsd.edu

Latest News

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation. Nature Immunology 2019. https://www.nature.com/articles/s41590-019-0550-7
Ptpn6 negatively regulates p38 MAPK activation to control TNF and IL-1a/b expression, and maintains Ripk1 function to prevent caspase-8- and Ripk3–Mlkl-dependent cell death and concomitant IL-1a/b release.


b-glucan dependent shuttling of conidia from neutrophils to macrophages occurs during fungal infection establishment. PLoS Biol 2019, 17(9): e3000113. PMID: 3148377
Neutrophils transfer pathogens to macrophages in a novel process called shuttling. The transfer of fungal pathogens is facilitated by Dectin-1 expression on macrophages. 

Research Activities

The production, function, and death of neutrophils is critical for host defense against pathogens. The laboratory studies a novel phenomena called shuttling, which involves the transfer of intracellular pathogens from neutrophils to macrophages. We also investigate how cell death signaling controls cytokine secretion, NET formation, and neutrophil lifespan.

References
M Speir, CJ Nowell, AA Chen, JA O’Donnell, IS Shamie, PR Lakin, AA D’Cruz, RO Braun, JJ Babon, RS Lewis, M Bliss-Moreau, I Shlomovitz, S Wang, LH Cengia, AI Stoica, R Hakem, MA Kelliher, LA O’Reilly, H Patsiouras, KE Lawlor, E Weller, NE Lewis, AW Roberts, M Gerlic, BA Croker. Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation. Nature Immunology 2019. doi:10.1038/s41590-019-0550-7.

V Pazhakh*, F Ellett*, BA Croker*, Joanne A. O’Donnell, L Pase, KE Schulze, RS Greulich, A Gupta, CC Reyes-Aldasoro, A Andrianopoulos, GJ Lieschke. β-glucan dependent shuttling of conidia from neutrophils to macrophages occurs during fungal infection establishment.  PLoS Biol 2019, 17(9): e3000113. *contributed equally. PMID: 3148377

AA D’Cruz, M Speir, M Bliss-Moreau, S Dietrich, S Wang, AA Chen, M Gavillet, A Al-Obeidi, KE Lawlor, JE Vince, M Kelliher, R Hakem, M Pasparakis, DA Williams, M Ericsson, BA Croker. MLKL activates PAD4-dependent NET formation in necroptotic neutrophils. Science Signaling 2018, 11, eaao1716. PMID: 30181240

Techniques/Expertise

Neutrophils, Macrophages, Hematopoietic Stem Cells, Cell Death, Inflammation, Innate Immunity

Disease Models

MRSA, Bone Marrow Failure, Neutrophilic Dermatoses, Sudden Cardiac Death

Genetically Modified Organisms

Ripk1, Shp1, Kcnj8, Dectin-1, Mlkl

Research Images

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Upcoming Events

  • Feb 17

    Lorne Infection and Immunity Conference 2021

    Completely virtual MORE INFO
  • Nov 28

    50th ASI Annual Scientific Meeting

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  • Feb 17

    Lorne Infection and Immunity Conference 2021

    Completely virtual MORE INFO