Dr Paul Ramsland

Vice Chancellor's Senior Research Fellow
School of Science
RMIT University

paul.ramsland@rmit.edu.au

Research Activities

Knowledge of the 3-D structure of individual proteins and their complexes with other proteins or small molecules (eg: inhibitors) is often crucial for understanding how these molecules perform their biological functions.Investigations are focused on solving crystal structures of antibodies, immune complexes and molecules that interact with the antibody portions of these immune complexes.

The objectives of the Ramsland Laboratory are:
  • To explore the structural biology of host-pathogen interactions, (pathogens are an agent – usually a microorganism – that cause a disease) particularly where immune system molecules are targeted by bacterial and viral ‘decoy’ proteins
  • To develop structural approaches for the design of antibodies with improved efficacy for immunotherapy in human diseases like cancer
  • To examine the structural and functional studies of recognition of carbohydrates and glycoproteins (structural glycobiology) in diseases and in the xenotransplantation setting (the process of transplanting organs from one species to another, especially from animals to humans).
Major techniques employed in laboratory
  • Crystal Growing: Protein samples are rapidly screened for initial crystallisation conditions. Crystals are optimised by fine screening of conditions and a variety of seeding techniques
  • X-ray Structure Determinations: Protein crystals are subjected to X-ray diffraction analyses and the 3-D structures are determined experimentally
  • Protein Modelling: Protein 3-D structures and their complexes with ligand (a molecule or ion bound to something, forming a complex) are predicted in silico using homology modelling and automated docking procedures.

Techniques/Expertise

  • Crystal Growing
  • X-ray Structure Determinations
  • Protein Modelling

Other members with similar research interests

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A/Prof Fasseli Coulibaly

Department of Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

Prof Bill Charman

Faculty of Pharmacy and Pharmaceutical Sciences Monash University SEE FULL PROFILE >

Prof Jamie Rossjohn FAA FLSW FAHMS FMedSci

Department of Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

Upcoming Events

  • Feb 27

    Antimicrobials 2020

    Melbourne Exhibition and Convention Centre MORE INFO
  • Mar 6

    Australasian Bone and Joint Infection Conference

    MORE INFO
  • Mar 15

    2020 Antibody Biology and Engineering Gordon Research Conference

    Ventura Beach Marriott MORE INFO