A/Prof Neil O'Brien-Simpson

Program Leader
Melbourne Dental School
University of Melbourne

neil.obs@unimelb.edu.au

Research Activities

  1. Host repsonse to bacterial outer membrane vesicles (OMVs)
  2. Vaccine design and development - synthetic peptides and recombinant proteins
  3. Evaluation of the host response to bacterial oral infection
  4. Role of γδT cells, NKT cells and innate immune cells in bacterial oral infection
  5. Antimicrobial peptide development.
  6. Nanomaterials for vaccine delivery.
  7. Nanomaterials as antimicrobial compounds

Techniques/Expertise

  1. Peptide synthesis and modification, HPLC etc.
  2. Flow cytometry, Bioplex, MACS and FACS sorting, T cell proliferation, cytokine assays (ELISPOT, Bioplex), cell culture (T cells and subsets, B cells, macrophages, epithelial, endothelial etc)

Collaborations

2. Prof Dale Godfrey (Dept Immunology and Microbiology, University of Melbourne).
3. Prof Malcolm McConville (Dept Biochemistry, University of Melbourne)1
Prof John Wade (Howard Florey Institute)
Prof Greg Qiao (Dept Engineering, University of Melbourne)
Dr Maria Liaskos
Prof Frances Separovic
A/Prof Andrea O'Connor
Prof Stuart Dashper

Disease Models

Bacterial induced bone loss
bacterial induced peritonitis
Sepsis

Genetically Modified Organisms

αβ-TCR-/-, γδTCR-/-, IL-4-/-, IL-13-/-

Other Lab Members

Ms Yan Tan (Research assistant)
Dr Jason Lenzo
Dr James Holden
Mr William Singleton
Dr Alexis Gonzalez

Other members with similar research interests

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A/Prof David Piedrafita

Federation University SEE FULL PROFILE >

Dr Hayley Newton

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Dr Mark Wickham

Chemistry and Life Sciences Phillips Ormonde Fitzpatrick SEE FULL PROFILE >

Upcoming Events

  • Jul 5

    Annual Meeting for the Australian Society for Microbiology 2020

    Melbourne Convention and Exhibition Centre MORE INFO
  • Jul 6

    10th International Symposium for Fish Parasitology and Australian Society for Parasitology Annual Co

    Shangri-La Hotel Cairns MORE INFO
  • Jul 28

    World Hepatitis Day

    MORE INFO