Prof Paul Hertzog

VIIN Co-convenor
Director
Centre for Innate Immunity and Infectious Diseases
Hudson Institute of Medical Research

+61 3 9594 7260
paul.hertzog@hudson.org.au

Research Activities

Overall interest is in the molecular regulation of signal transduction in innate immunity. In particular our group is interested in pattern recognition receptor signaling, the elicited transcriptional responses including IRF, STAT, ETS and NFκB pathways and the ensuing cytokine responses. The particular cytokines of interest are the type I interferons (IFNs). We investigate the mechanisms of signaling beginning at reengagement of the receptors, IFNAR1 and IFNAR2. Receptor function is studies using genetically modified mouse models, protein-protein interactions, structural biology, imaging and signal transduction studies. We have discovered a new family member involved in mucosal immunity. Another aspect of signaling is negative regulation, particularly that mediated by the SOCS family of cytokines. We are investigating their regulation of IFN (α, β and γ) as well as TLR signaling. One outcome of the nature of our research is a growing capability in cell based screens for activators and inhibitors of innate immunity signaling. We are investigating the global nature of TLR/cytokine/interferon signaling using microarrays to analyse gene transcriptional profiling incorporated with bioinformatics to predict regulatory networks and identify novel transcriptional regulation candidates. One outcome is the INTERFEROME database for annotating response pathways. We have a longstanding expertise in the generation of genetically modified mice and their pathophysiological characterisation. Disease models include viral and bacterial infections and models of tumourigenesis. Through an international program, MONMAN, in collaboration with Norcomm/Canada we are generating reporter mice for inflammation /innate immune pathways.

Techniques/Expertise

Molecular signaling (protein-protein interactions, IP-Westerns, kinases)
Generation and characterisation of genetically modified mice
Animal models of infectious disease, inflammation and cancer
Bioinformatics and Microarray profiling (human and mouse)
Gene regulatory mechanisms ( EMSA, translocation, ChIP, reporters, promoter mapping)
Flow cytometry
Immunoassays (antibody-based; cell mediated, immpunophenotyping, monoclonal generation)

Collaborations

Prof Jamie Rossjohn
Prof Elizabeth Hartland
B. Parker (Peter MacCallum) – Innate immune pathways in metastasis
A. Cunningham (NSW) – HSV and HIV infections
C. James – Influenza infections and IFNs
L.O’Neill (Trinity College, Dublin) – TLR signaling
E. Latz (Bonn, Germany) – PRR signaling
G. Hicks (Manitoba) – GMM models of disease
R.D. Schreiber ( Washington U, St Louis) – type I IFNs
P. Pitha-Rowe (John’s Hopkins, Baltimore) – antiviral f IFNs and IRFs
Hong Tang (CAS, Beijing) – infection and immunity

Disease Models

Variety of viral and bacterial infection models in mice
Induced and transplantable models

Genetically Modified Organisms

Assorted genetically modified mouse models associated with TLR signaling, cytokine signaling (IFNs IFNARs, STATs, SOCS, etc) and ETS transcription factors (ETS1, ETS2, ELF3, ELF5, GABPa). Include conventional and conditionally targeted lines.

Other Lab Members

Dr Niamh Mangan
Dr Nicky de Weerd
Sam Forster
Jodee Gould
Dr Nollaig Bourke
Dr Michelle Tate
Tony Matthews
Kellly Rodwell
Dr Ross Chapman
Dr Jamie Gearing
Dr Helen Cumming

Other members with similar research interests

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Dr Scott Mueller

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

A/Prof Alex Andrianopoulos

Department of Genetics University of Melbourne SEE FULL PROFILE >

Dr Alyssa Barry

Infection and Immunity Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Upcoming Events

  • Feb 14

    Lorne Infection and Immunity Conference 2018

    Cumberland Lorne Resort REGISTER | MORE INFO
  • Mar 1

    18th International Congress on Infectious Diseases

    Sheraton Buenos Aires MORE INFO
  • Mar 15

    Eradicate Cancer 2018

    Melbourne Convention and Exhibition Centre MORE INFO