Prof Paul Hertzog

VIIN Co-convenor
Centre for Innate Immunity and Infectious Diseases
Hudson Institute of Medical Research

+61 3 9594 7260

Research Activities

Overall interest is in the molecular regulation of signal transduction in innate immunity. In particular our group is interested in pattern recognition receptor signaling, the elicited transcriptional responses including IRF, STAT, ETS and NFκB pathways and the ensuing cytokine responses. The particular cytokines of interest are the type I interferons (IFNs). We investigate the mechanisms of signaling beginning at reengagement of the receptors, IFNAR1 and IFNAR2. Receptor function is studies using genetically modified mouse models, protein-protein interactions, structural biology, imaging and signal transduction studies. We have discovered a new family member involved in mucosal immunity. Another aspect of signaling is negative regulation, particularly that mediated by the SOCS family of cytokines. We are investigating their regulation of IFN (α, β and γ) as well as TLR signaling. One outcome of the nature of our research is a growing capability in cell based screens for activators and inhibitors of innate immunity signaling. We are investigating the global nature of TLR/cytokine/interferon signaling using microarrays to analyse gene transcriptional profiling incorporated with bioinformatics to predict regulatory networks and identify novel transcriptional regulation candidates. One outcome is the INTERFEROME database for annotating response pathways. We have a longstanding expertise in the generation of genetically modified mice and their pathophysiological characterisation. Disease models include viral and bacterial infections and models of tumourigenesis. Through an international program, MONMAN, in collaboration with Norcomm/Canada we are generating reporter mice for inflammation /innate immune pathways.


Molecular signaling (protein-protein interactions, IP-Westerns, kinases)
Generation and characterisation of genetically modified mice
Animal models of infectious disease, inflammation and cancer
Bioinformatics and Microarray profiling (human and mouse)
Gene regulatory mechanisms ( EMSA, translocation, ChIP, reporters, promoter mapping)
Flow cytometry
Immunoassays (antibody-based; cell mediated, immpunophenotyping, monoclonal generation)


Prof Jamie Rossjohn
Prof Elizabeth Hartland
B. Parker (Peter MacCallum) – Innate immune pathways in metastasis
A. Cunningham (NSW) – HSV and HIV infections
C. James – Influenza infections and IFNs
L.O’Neill (Trinity College, Dublin) – TLR signaling
E. Latz (Bonn, Germany) – PRR signaling
G. Hicks (Manitoba) – GMM models of disease
R.D. Schreiber ( Washington U, St Louis) – type I IFNs
P. Pitha-Rowe (John’s Hopkins, Baltimore) – antiviral f IFNs and IRFs
Hong Tang (CAS, Beijing) – infection and immunity

Disease Models

Variety of viral and bacterial infection models in mice
Induced and transplantable models

Genetically Modified Organisms

Assorted genetically modified mouse models associated with TLR signaling, cytokine signaling (IFNs IFNARs, STATs, SOCS, etc) and ETS transcription factors (ETS1, ETS2, ELF3, ELF5, GABPa). Include conventional and conditionally targeted lines.

Other Lab Members

Dr Niamh Mangan
Dr Nicky de Weerd
Sam Forster
Jodee Gould
Dr Nollaig Bourke
Dr Michelle Tate
Tony Matthews
Kellly Rodwell
Dr Ross Chapman
Dr Jamie Gearing
Dr Helen Cumming

Other members with similar research interests

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Prof Brendan Jenkins

Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research SEE FULL PROFILE >

Dr Zoe Dyson

Department of Biochemistry and Molecular Biology University of Melbourne SEE FULL PROFILE >

Dr Louis Schofield

Infection and Immunity Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Upcoming Events

  • Aug 24

    IgV Annual Scientific Meeting

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  • Sep 25

    Global Virus Network Meeting 2017

    Doherty Institute, Melbourne, Australia MORE INFO
  • Oct 16

    LISSSD 2017

    Sofitel Fiji Resort and Spa MORE INFO